High‐frequency audiometry in platinum ototoxicity

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid tumors. As determined through reverse transcriptase-PCR (RT-PCR), quantitative RT-PCR, Western blot, and immunohistochemistry, mouse CTR1 (Ctr1) was found to be abundantly expressed and hi...

In-situ audiometry: How close is it to conventional audiometry?

Technology in the hearing aid industry is ever changing. One of the many features that may improve accuracy of hearing aid fi ttings and patients ’ satisfaction is the inception of in-situ audiometry, which allows the clinician to measure hearing thresholds with a hearing aid in the patient ’ s ear. Objective : The present study aimed to investigate the validity of in-situ audiometry measured w...

Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity.

Platinum-based chemotherapeutic agents, such as carboplatin and cisplatin, are effective against many human tumors, but their use may be limited by a high incidence of ototoxicity. Delayed administration of the chemoprotective agent sodium thiosulfate (STS) reduces the ototoxicity of carboplatin in a guinea-pig model, when given up to 8 h after the chemotherapy, and also reduces hearing loss in...

In-situ audiometry

Anti-cancer characteristics and ototoxicity of platinum(II) amine complexes with only one leaving ligand

Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(diethylenetriamine)Cl, [Pt(dien)Cl]+, and Pt(N,N-diethyldiethylenetriamine)Cl, [Pt(Et2dien)Cl]+, a...